CNS Micro Animation ／ Transsynaptic degeneration

Cellular Neuropathology

Core curriculum

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■Anterograde degenation

■Retrograde degeneration

■Transsynaptic degeneration

■Axonal dystrophy

■Axonal swelling

■Axonal swelling induced by trauma

■Asteroid body in the dendrite of the Purkinje cell

■Grumose degeneration

■Empty basket

■Fat granule cell (macrophage)

■Iron granule cell

■Neuronophagia

■Isomorphic gliosis

■Foamy spheroid body (1)

■Foamy spheroid body (2)

■Role of the nodeof Ranvier

■Demyelination (primary)

■Myelin destruction (secondary change)

■Hippocampal sclerosis

■Neuronal clustering

■Persistent columnar architecture

■Laminar disorganization

■Leptomeningeal heterotopia

■Neuronal migration (Inside-out pattern)

■Neuronal migration (Climbing pattern)

Transsynaptic degeneration

Transneuronal degeneration is neuronal degeneration that is passed on to other connected neuronal fibers. This is the spread of degeneration via synapses and is also referred to as transsynaptic degeneration.