HOMECNS Micro Animation:Micro

CNS Macro Animation:Micro

Grumose degeneration

Grumose degeneration of dentate nucleus is specific degeneration of the dentate nucleus as a result of neuronal loss, while aggregates of eosinophilic cloud-like structures surrounding or slightly away from the neurons of the cerebellar dentate nucleus are observed on H&E staining. With silver staining such as Bodian, these structures are faint cloud-like formations with no stain affinity and observed as forms of argyrophilic small granules, slightly large aggregates, and ring-like formations. The cloud-like and microgranular structures are thought to be fibers sprouting from the axonal terminals of Purkinje cells, while the slightly large aggregates and ring-like structures are swollen axonal terminals.