The following findings are generally observed in abnormal ependymal cell changes:
Granulation is often observed when ependymal cells are lost and scarring occurs. Although common in the hydrocephalus, the change is rather nonspecific.
Gliosis can form in the subependymal cells; however, it generally has little clinical significance. Highly intense gliosis can form in tuberous sclerosis, which is called Shaslan’s gliosis.
In cytomegalovirus infection, intranuclear inclusions form in neurons, glial cells, and ependymal cells.
Ependymal cells are often found buried in the cerebral parenchyma but not in the cerebral ventrical wall.