EBA&N

HOME ＞ Sample room ＞ Cellular Neuropathology

Neuron

■Alzheimer’s neurofibrillary tangle

■Hirano body

■Pick body

■Lewy-body（Brainstem type）

■Cortical Lewy body

■Dysplastic neuron with cytomegaly

■Balloon cell

■Negri body

■Polyglutamine inclusion

■Calcification

■Basophilic inclusion

■Neuronal inclusion in ALS-D

■Skein-like inclusion

■Bunina body

■Achromasia

■Lewy-body like hyaline inclusion

■Lafora body

Neurites

■Spheroid

■Dystrophic axon

■Cactus

■Asteroid body

■Empty basket without Purkinje cell

■Torpedo

■Grumose degeneration

■Lewy neuritis

■Neuropil thread

■Senile plaque

Astrocyte

■Tufted astrocyte

■Gemistocytic astrocyte

■Rosenthal fiber

■Cytomegalovirus inclusion

■Isomorphic gliosis

■Bergmann glia’s proliferation

■Shaslan’s gliosis

■Anisomorphic gliosis

■Astrocytic plaques

■Dysplastic astrocyte

■Corpora amylacea

Oligodendroglia

■Glial cytoplasmic inclusion

■JC virus inclusion

■Glial coiled body

■Argyrophilic thread

Macrophage

■Multinucleic giant cell with AIDS leukoencephalopathy

■Globoid cell

■Fat-granule cell

■Iron-granule cell

■Neuronophagia

■Langhans giant cell

Myelin destruction

■Primary myelin destruction

■Secondary myelin destruction

Axonal degeneration

■Anterograde axonal degeneration

■Retrograde axonal degeneration

■Grumose degeneration

Alzheimer’s neurofibrillary tangle

Dementia such as Alzheimer’s disease and normal aging cause the accumulation of insoluble phosphorylated tau proteins, which accumulate as abnormal fiber formations called NFTs. NFTs are divided into flame-shaped and globose-shaped NFTs according to the presence of argyrophilic and morphological content. They are also divided by intracellular and extracellular locale. With H&E staining, they appear as relatively refractile fiber bundles; however, old tangles may appear eosinophilic. NFTs have strong argyrophilic properties. With GB staining, they are clearly stained black and are therefore very easily detected. However, care should be taken because GB stained-substances are not always NFTs. In addition to aging and dementia, NFTs appear in patients with subacute sclerosis pancencephalitis, sequelae of perinatal brain damage, elderly patients with Nieman–Pick disease type C, and patients with delayed head trauma (boxer’s dementia).