HOMESample room > Cellular Neuropathology

Cellular Neuropathology

Neuron
Alzheimer’s neurofibrillary tangle
Hirano body
Pick body
Lewy-body(Brainstem type)
Cortical Lewy body
Dysplastic neuron with cytomegaly
Balloon cell
Negri body
Polyglutamine inclusion
Calcification
Basophilic inclusion
Neuronal inclusion in ALS-D
Skein-like inclusion
Bunina body
Achromasia
Lewy-body like hyaline inclusion
Lafora body
Neurites
Spheroid
Dystrophic axon
Cactus
Asteroid body
Empty basket without Purkinje cell
Torpedo
Grumose degeneration
Lewy neuritis
Neuropil thread
Senile plaque
Astrocyte
Tufted astrocyte
Gemistocytic astrocyte
Rosenthal fiber
Cytomegalovirus inclusion
Isomorphic gliosis
Bergmann glia’s proliferation
Shaslan’s gliosis
Anisomorphic gliosis
Astrocytic plaques
Dysplastic astrocyte
Corpora amylacea
Oligodendroglia
Glial cytoplasmic inclusion
JC virus inclusion
Glial coiled body
Argyrophilic thread
Macrophage
Multinucleic giant cell with AIDS leukoencephalopathy
Globoid cell
Fat-granule cell
Iron-granule cell
Neuronophagia
Langhans giant cell
Myelin destruction
Primary myelin destruction
Secondary myelin destruction
Axonal degeneration
Anterograde axonal degeneration
Retrograde axonal degeneration
Grumose degeneration

Alzheimer’s neurofibrillary tangle

Dementia such as Alzheimer’s disease and normal aging cause the accumulation of insoluble phosphorylated tau proteins, which accumulate as abnormal fiber formations called NFTs. NFTs are divided into flame-shaped and globose-shaped NFTs according to the presence of argyrophilic and morphological content. They are also divided by intracellular and extracellular locale. With H&E staining, they appear as relatively refractile fiber bundles; however, old tangles may appear eosinophilic. NFTs have strong argyrophilic properties. With GB staining, they are clearly stained black and are therefore very easily detected. However, care should be taken because GB stained-substances are not always NFTs. In addition to aging and dementia, NFTs appear in patients with subacute sclerosis pancencephalitis, sequelae of perinatal brain damage, elderly patients with Nieman–Pick disease type C, and patients with delayed head trauma (boxer’s dementia).

HE stain

Most of NFTs is eosinophilic.

Bodian stain

NFTs show strong argyrophilia.

Phosphorylated tau stain

NFTs are strongly stained with phosphorylated tau stain.

Gallyas stain

NFTs are stained black with Gallyas stain.


HE stain

HE stain

Bodian stain

Bodian stain

Phosphorylated tau stain

Phosphorylated tau stain

Gallyas stain

Gallyas stain